Detection of type IV collagenase activity in malignant ascites

Type IV Collagenase (Mr 72,000) Expression in Human Prostate: Benign and Malignant Tissue1

The expression of type IV collagenase (Mr 72,000) has been examined in tissues from patients with benign prostatic hyperplasia (6 patients) and varying Gleason grades of malignant prostate cancer (18 patients). Immunoperoxidase labeling indicated that expression of the type IV colla genase was weak or nonexistent in benign tissue but consistently strong in the glandular and ductal epithelial ce...

Type IV collagenase (M(r) 72,000) expression in human prostate: benign and malignant tissue.

The expression of type IV collagenase (M(r) 72,000) has been examined in tissues from patients with benign prostatic hyperplasia (6 patients) and varying Gleason grades of malignant prostate cancer (18 patients). Immunoperoxidase labeling indicated that expression of the type IV collagenase was weak or nonexistent in benign tissue but consistently strong in the glandular and ductal epithelial c...

Activin A Stimulates Type IV Collagenase

Neutrophil accumulation correlates with type IV collagenase/gelatinase activity in endotoxin induced uveitis.

BACKGROUND/AIM Anterior uveitis is a common inflammatory ocular disease characterised by protein accumulation and leucocyte infiltration in the anterior chamber. The aim of this study was to determine the expression of gelatinases in the aqueous humour (AH) and uvea in an animal model of endotoxin induced uveitis (EIU). METHODS EIU was established in Lewis rats following an intraperitoneal in...

Tumorigenic Cell Lines Type IV Collagenase and Interstitial Collagenase in Human

The regulation of M, 72,000 type IV collagenase and interstitial collagenase expression was studied in vitro. Three tumorigenic human cell lines were used, together with human fetal lung fibroblasts as a nontumorigenic control. M, 72,000 type IV collagenase was expressed constitutively by all four cell lines, whereas only A20S8 melanoma cells exhibited constitutive expression of interstitial co...